abstract：:1. Adenosine A(1) receptors (A(1)R) play an important role in cardioprotection against hypoxic damage and the opening of mitochondrial permeability transition pores (MPTP) is central to the regulation of cell apoptosis and necrosis. However, it is still unclear whether A(1)R open MPTP in hypoxic cardiomyocytes. 2. The...

journal_title：Clinical and experimental pharmacology & physiology

authors： Xiang F,Huang YS,Zhang DX,Chu ZG,Zhang JP,Zhang Q

更新日期：2010-03-01 00:00:00

abstract：:1. The present study examined the cytosolic Ca(2+) regulatory machinery involved in the vasorelaxation produced by petasin, a sesquiterpene isolated from Petasites formosanus. 2. Aortic rings isolated from Sprague-Dawley rats were exposed to petasin (0.01-100 micromol/L) to elucidate its vascular effects on isometric ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Wang GJ,Lin YL,Chen CH,Wu XC,Liao JF,Ren J

更新日期：2010-03-01 00:00:00

abstract：:1. The maintenance of skeletal muscle mass is determined by a fine balance between protein synthesis and protein degradation. Skeletal mass is increased when there is a net gain in protein synthesis, which can occur following progressive exercise training. In contrast, skeletal muscle mass is lost when degradation occ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Russell AP

更新日期：2010-03-01 00:00:00

abstract：:1. Resveratrol (RSV), a polyphenol in red wine, exhibits cardioprotective effects in vitro, such as inhibition of angiotensin II- or phenylephrine-induced cardiomyocyte hypertrophy in rat neonatal myocyte cultures and suppression of cardiac fibroblast proliferation. The aim of the present study was to investigate the ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Yang DL,Zhang HG,Xu YL,Gao YH,Yang XJ,Hao XQ,Li XH

更新日期：2010-02-01 00:00:00

abstract：:1. Stroke is the second most common cause of death and a major cause of disability worldwide. Despite increasing knowledge of the cellular and molecular mechanisms that occur in stroke, there are still large gaps in our understanding that are impeding therapeutic progress. In addition, there are no drugs yet that can ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Sun XL,Hu G

更新日期：2010-02-01 00:00:00

abstract：:1. Chronic electrical stimulation of the carotid sinuses has provided unique insight into the mechanisms that cause sustained reductions in blood pressure during chronic suppression of central sympathetic outflow. 2. Because renal denervation does not abolish the sustained fall in arterial pressure in response to baro...

journal_title：Clinical and experimental pharmacology & physiology

authors： Iliescu R,Lohmeier TE

更新日期：2010-02-01 00:00:00

abstract：:1. Evidence gathered in recent years has revealed microRNAs (miRNAs) fine-tune gene expression and play an important role in various cellular processes, including cell growth, differentiation, proliferation and apoptosis. 2. The present review summarizes current knowledge of miRNA pathways in the pathogenesis of cance...

journal_title：Clinical and experimental pharmacology & physiology

authors： Tsai LM,Yu D

更新日期：2010-01-01 00:00:00

abstract：:1. Telomeres (ends of chromosomes) undergo constant remodelling during cell development, proliferation and differentiation, as well as in neoplastic cell immortalization and transformation. How the cellular microenvironment influences telomere remodelling (lengthening or shortening) remains largely unknown. 2. Recentl...

journal_title：Clinical and experimental pharmacology & physiology

authors： Liu JP,Nicholls C,Chen SM,Li H,Tao ZZ

更新日期：2010-01-01 00:00:00

abstract：:1. Ghrelin is a multifunctional peptide hormone that affects various processes, including growth hormone and insulin release, appetite regulation, gut motility, metabolism and cancer cell proliferation. Ghrelin is produced in the stomach and in other normal and pathological cell types. It may act as an endocrine or au...

journal_title：Clinical and experimental pharmacology & physiology

authors： Seim I,Amorim L,Walpole C,Carter S,Chopin LK,Herington AC

更新日期：2010-01-01 00:00:00

abstract：:1. The most usual form of chronic hypoxia in humans is the intermittent hypoxia resulting from obstructive sleep apnoea (OSA). The OSA syndrome is a highly prevalent sleep breathing disorder that is considered an independent risk factor for hypertension and cardiovascular diseases. Endothelial dysfunction, oxidative s...

journal_title：Clinical and experimental pharmacology & physiology

authors： Iturriaga R,Moya EA,Del Rio R

更新日期：2009-12-01 00:00:00

abstract：:Summary 1. The non-selective K(+) channel blocker 4-aminopyridine (4-AP) has shown clinical efficacy in the treatment of neurological disorders such as multiple sclerosis. The clinical usefulness of 4-AP is hampered by its ability to produce seizures. Nerispirdine, an analogue of 4-AP, is currently under clinical inve...

journal_title：Clinical and experimental pharmacology & physiology

authors： Smith C,Kongsamut S,Wang H,Ji J,Kang J,Rampe D

更新日期：2009-11-01 00:00:00

abstract：:1. The serotonin transporter (SERT) is strongly implicated in the pathogenesis of pulmonary arterial hypertension (PAH) in patients and animal models. Inhibitors of SERT have been reported to attenuate or reverse experimental PAH, which makes them potential therapeutic options for the treatment of PAH in humans. Howev...

journal_title：Clinical and experimental pharmacology & physiology

authors： Zhu SP,Mao ZF,Huang J,Wang JY

更新日期：2009-08-01 00:00:00

abstract：:1. Congenital long QT syndrome (LQTS) is a genetically heterogeneous disease. The aim of the present study was to identify the gene mutation in a Chinese family with LQTS and investigate the functional changes associated with the mutation. 2. Polymerase chain reaction and DNA sequencing were used to screen for the KCN...

journal_title：Clinical and experimental pharmacology & physiology

authors： Yang HT,Sun CF,Cui CC,Xue XL,Zhang AF,Li HB,Wang DQ,Shu J

更新日期：2009-08-01 00:00:00

abstract：:1. Chromium picolinate (CrPic) has been recommended as an alternative therapeutic regimen for Type 2 diabetes mellitus (T2DM). However, the molecular mechanism underlying the action of CrPic is poorly understood. 2. Using normal and insulin-resistant 3T3-L1 adipocytes, we examined the effects of CrPic on the gene tran...

journal_title：Clinical and experimental pharmacology & physiology

authors： Wang YQ,Dong Y,Yao MH

更新日期：2009-08-01 00:00:00

abstract：:1. Inhibiting the renin-angiotensin-aldosterone system prevents left ventricular (LV) remodelling after myocardial infarction (MI). 2. The present study was designed to assess the effects of a combination of perindopril and losartan on LV remodelling, cardiac function and serum procollagen type III amino terminal pept...

journal_title：Clinical and experimental pharmacology & physiology

authors： Li L,Liu RY,Zhao XY,Zhang JY,Jia M,Lu PQ

更新日期：2009-07-01 00:00:00

abstract：:1. Iron overload contributes to the pathogenesis of various diseases and directly induces tissue injury. In the present study, we investigated the relationship between heart and liver injury induced by iron overload and cellular endoplasmic reticulum (ER) stress to explore the molecular mechanism of iron overload-indu...

journal_title：Clinical and experimental pharmacology & physiology

authors： Lou LX,Geng B,Chen Y,Yu F,Zhao J,Tang CS

更新日期：2009-07-01 00:00:00

abstract：:1. Erlotinib, a small-molecule epidermal growth factor receptor-tyrosine kinase (EGFR-TK) inhibitor, has been approved for the management of advanced non-small cell lung cancer. The aim of the present study was to investigate whether erlotinib exerts potent antitumour activities through the reactive oxygen species (RO...

journal_title：Clinical and experimental pharmacology & physiology

authors： Qian X,Li J,Ding J,Wang Z,Zhang W,Hu G

更新日期：2009-05-01 00:00:00

abstract：:1. Mechanical stretch leads to cardiac hypertrophy and may ultimately cause heart failure. However, the effect of mechanical stretch on gene induction in cardiomyocytes remains to be determined. 2. In the present study, we compared transcript profiles of mechanically stretched neonatal rat cardiomyocytes with those of...

journal_title：Clinical and experimental pharmacology & physiology

authors： Cheng TH,Chen JJ,Shih NL,Lin JW,Liu JC,Chen YL,Chen CH,Chen JJ

更新日期：2009-05-01 00:00:00

abstract：:1. Pulmonary veins are the most important focus for the initiation of atrial fibrillation. Diabetes mellitus may be associated with hypertonicity and increased occurrence of atrial fibrillation. 2. The purpose of the present study was to investigate whether hypertonicity alters the electrophysiological characteristics...

journal_title：Clinical and experimental pharmacology & physiology

authors： Lee SH,Chen YC,Cheng CC,Higa S,Chen YJ,Chen SA

更新日期：2009-04-01 00:00:00

abstract：:1. The aim of the present study was to explore the effects of CPU0213, a dual endothelin ET(A)/ET(B) receptor antagonist, and nifedipine, a calcium antagonist, in relieving pulmonary hypertension (PH). Both endothelin receptor and calcium antagonists have been reported to be effective in alleviating the remodelling of...

journal_title：Clinical and experimental pharmacology & physiology

authors： Cui B,Cheng YS,Dai DZ,Li N,Zhang TT,Dai Y

更新日期：2009-02-01 00:00:00

abstract：:1. The aims of the present study were to investigate the pharmacological effects of quercetin on wild-type (WT) and mutant (I502A) human (h) Kv1.5 channel currents (I(kur)) and to identify whether mutation in the S6 segment is critical to activation of I(kur) by quercetin. 2. Experiments were performed on WT and site-...

journal_title：Clinical and experimental pharmacology & physiology

authors： Yang L,Ma JH,Zhang PH,Zou AR,Tu DN

更新日期：2009-02-01 00:00:00

abstract：:1. Currently, there is no satisfactory treatment for pulmonary fibrosis. Emodin, a component in Chinese herbs, has been shown to have an antifibrotic effect on pancreatic fibrosis and liver fibrosis. In the present study, we tested the hypothesis that emodin may attenuate the development of pulmonary fibrosis. 2. Mice...

journal_title：Clinical and experimental pharmacology & physiology

authors： Chen XH,Sun RS,Hu JM,Mo ZY,Yang ZF,Jin GY,Guan WD,Zhong NS

更新日期：2009-02-01 00:00:00

abstract：:1. Despite the array of sophisticated imaging techniques available for biological applications, none of the standard biomedical techniques adequately provides the capability to measure motion and flow. Those techniques currently in use are particularly lacking in spatial and temporal resolution. 2. Herein, we introduc...

journal_title：Clinical and experimental pharmacology & physiology

authors： Fouras A,Dusting J,Sheridan J,Kawahashi M,Hirahara H,Hourigan K

更新日期：2009-02-01 00:00:00

abstract：:1. The aim of the present study was to perform an in vivo estimation of the Michaelis-Menten constants of the major metabolic pathways of paracetamol (APAP). 2. A two-occasion, single-dose cross-over trial was performed using 60 and 90 mg/kg doses of APAP in healthy patients undergoing third molar dental extraction. P...

journal_title：Clinical and experimental pharmacology & physiology

authors： Reith D,Medlicott NJ,Kumara De Silva R,Yang L,Hickling J,Zacharias M

更新日期：2009-01-01 00:00:00

abstract：:1. Tissue plasminogen activator (tPA) has both fibrinolytic and anti-inflammatory activity. These properties may be useful in treating inflammatory lung diseases, such as acute respiratory distress syndrome (ARDS). 2. We have previously demonstrated the feasibility of targeted pulmonary delivery of tPA. As part of our...

journal_title：Clinical and experimental pharmacology & physiology

authors： Stringer KA,Tobias M,Dunn JS,Campos J,Van Rheen Z,Mosharraf M,Nayar R

更新日期：2008-12-01 00:00:00

abstract：:1. RNA interference in vivo has tremendous potential, both with respect to the elucidation of protein function in animals and as a therapeutic platform in humans. In vitro, short interfering RNA (siRNA) has been shown to completely silence gene expression in mammalian cells at low picomolar concentrations. 2. Although...

journal_title：Clinical and experimental pharmacology & physiology

authors： White PJ

更新日期：2008-11-01 00:00:00

abstract：:The aim of the present study was to determine the effects of increased cAMP levels in response to pituitary adenylate cyclase-activating polypeptide 27 (PACAP27) on atrial atrial natriuretic peptide (ANP) secretion in rabbit atria. A perfused beating atrial model was used in the present study and cAMP efflux and ANP l...

journal_title：Clinical and experimental pharmacology & physiology

authors： Zhang Y,Liu LP,Liang ZL,Li XL,Jin YZ,Cui X

更新日期：2008-10-01 00:00:00

abstract：:The pharmacological actions of 2,6-di-tert-butyl-4-(3-hydroxy-2-spiropentylpropyl)-phenol (BSPP), a putative presynaptic GABA(B) receptor modulator, were examined in electrically stimulated rat neocortical brain slices preloaded with [3H]-GABA or [3H]-glutamic acid. At 10 mmol/L, BSPP inhibited the release of [3H]-GAB...

journal_title：Clinical and experimental pharmacology & physiology

authors： Parker DA,Marino V,Ong J,Puspawati NM,Prager RH

更新日期：2008-09-01 00:00:00

abstract：:Central administration of choline increases blood pressure in normotensive and hypotensive states by increasing plasma concentrations of vasopressin and catecholamines. We hypothesized that choline could also modulate the renin-angiotensin pathway, the third main pressor system in the body. Plasma renin activity (PRA)...

journal_title：Clinical and experimental pharmacology & physiology

authors： Isbil-Buyukcoskun N,Ilcol YO,Cansev M,Hamurtekin E,Ozluk K,Ulus IH

更新日期：2008-09-01 00:00:00

abstract：:Members of the transient receptor potential (TRP) channel superfamily are present in vascular smooth muscle cells and play important roles in the regulation of vascular contractility. The TRPC3 and TRPC6 channels are activated by stimulation of several excitatory receptors in vascular smooth muscle cells. Activation o...

journal_title：Clinical and experimental pharmacology & physiology

authors： Brayden JE,Earley S,Nelson MT,Reading S

更新日期：2008-09-01 00:00:00

abstract：:Cardiotoxin (CTX) III, a basic polypeptide with 60 amino acid residues isolated from Naja naja atra venom, has been reported to have anticancer activity. In the present study, we investigated the mechanisms underlying the anticancer activity of CTX III in human leukaemia (HL-60 cells). Cardiotoxin III activated the en...

journal_title：Clinical and experimental pharmacology & physiology

authors： Chien CM,Yang SH,Chang LS,Lin SR

更新日期：2008-09-01 00:00:00

abstract：:1. The present study was performed to test the hypothesis that the reactive oxygen species (ROS)-angiotensinogen (AGT)-renin angiotensin system (RAS) axis is sequentially activated in the development of diabetic nephropathy in Zucker diabetic fatty (ZDF) obese rats. 2. Genetic pairs of male ZDF obese and control ZDF l...

journal_title：Clinical and experimental pharmacology & physiology

authors： Miyata K,Ohashi N,Suzaki Y,Katsurada A,Kobori H

更新日期：2008-08-01 00:00:00

abstract：:1. The aim of the present study was to characterize the source of plasma catecholamines induced by centrally administered glucagon-like peptide-1 (GLP-1), with regard to brain prostanoids, in urethane-anaesthetized rats. 2. Glucagon-like peptide-1 and other compounds were administered intracerebroventricularly (i.c.v....

journal_title：Clinical and experimental pharmacology & physiology

authors： Arai J,Okada S,Yamaguchi-Shima N,Shimizu T,Sasaki T,Yorimitsu M,Wakiguchi H,Yokotani K

更新日期：2008-08-01 00:00:00

abstract：:1. Previous studies have demonstrated progressive ventricular hypertrophy, dilatation and contractile depression in response to chronic volume overload. Whether this decompensation was related to intrinsic myocyte dysfunction was not clear. The present study evaluated ventricular myocyte function at critical times dur...

journal_title：Clinical and experimental pharmacology & physiology

authors： Ding YF,Brower GL,Zhong Q,Murray D,Holland M,Janicki JS,Zhong J

更新日期：2008-07-01 00:00:00

abstract：:1. The present study evaluated changes in autonomic control of the cardiovascular system in conscious rats following blockade of endothelin (ET) receptors with bosentan. 2. Rats were treated with bosentan or vehicle (5% gum arabic) for 7 days by gavage. 3. Baseline heart rate (HR) was higher in the bosentan-treated gr...

journal_title：Clinical and experimental pharmacology & physiology

authors： Souza HC,Terzini GC,da Silva VJ,Martins-Pinge MC,Salgado HC,Salgado MC

更新日期：2008-07-01 00:00:00

abstract：:1. Inflammation, particularly the pro-inflammatory cytokine tumour necrosis factor (TNF), increases necrosis of skeletal muscle. Depletion of inflammatory cells, such as neutrophils, cromolyn blockade of mast cell degranulation or pharmacological blockade of TNF reduces necrosis of dystrophic myofibres in the mdx mous...

journal_title：Clinical and experimental pharmacology & physiology

authors： Grounds MD,Radley HG,Gebski BL,Bogoyevitch MA,Shavlakadze T

更新日期：2008-07-01 00:00:00

abstract：:1. Free radical-induced lipid peroxidation and changes in protein and nucleic acid structures can result in various human ailments, including ageing, neurodegenerative disorders and cancer. High body fat or dietary fat further enhances the free radical-mediated pathogenesis of various diseases. 2. In the present study...

journal_title：Clinical and experimental pharmacology & physiology

authors： Ajith TA,Riji T,Anu V

更新日期：2008-05-01 00:00:00

abstract：:1. The worldwide epidemic of obesity in adults has been mirrored in children in developed and developing countries. 2. Central obesity appears to be driving a cluster of abnormalities often referred to as the metabolic syndrome. 3. The definition of the metabolic syndrome in children is not suited to arbitrary cut-off...

journal_title：Clinical and experimental pharmacology & physiology

authors： Beilin L,Huang RC

更新日期：2008-04-01 00:00:00

abstract：:1. Indices quantifying blood pressure (BP) and heart rate (HR) variability have been recently developed and may be used to assess the contribution of the autonomic nervous system to cardiovascular fluctuations. 2. Cardiovascular variables were measured in eight conscious mice equipped with a BP telemetric device. Each...

journal_title：Clinical and experimental pharmacology & physiology

authors： Laude D,Baudrie V,Elghozi JL

更新日期：2008-04-01 00:00:00

abstract：:1. Although measuring the rate of firing of multi-unit muscle sympathetic nerve activity (MSNA) has provided important information in many aspects of cardiovascular medicine, measuring single-unit vasoconstrictor activity provides a better understanding of the possible mechanisms underlying disturbed sympathetic nervo...

journal_title：Clinical and experimental pharmacology & physiology

authors： Lambert E,Dawood T,Schlaich M,Straznicky N,Esler M,Lambert G

更新日期：2008-04-01 00:00:00